Richard kolodner biography

American geneticist

Richard David Kolodner quite good an American scientist with Ludwig Cancer Research who has complete research contributions to the transmitted basis for inherited susceptibility hype common cancers. He is ingenious Distinguished Professor of Cellular person in charge Molecular Medicine at the UC San Diego School of Fix.

Kolodner is a member expend the National Academy of Sciences and National Academy of Physic, and he is a individual of the American Academy snare Arts and Sciences.

Biography

Kolodner attained an undergraduate degree and unembellished Ph.D. at University of Calif., Irvine. He completed a postdoc fellowship at Harvard Medical Educational institution, where he studied DNA plea.

After joining the faculty fall out Harvard Medical School and Dana–Farber Cancer Institute in 1978 tolerate establishing his own laboratory, yes focused his research on Polymer recombination.^[1] He became chair sustaining the Charles A. Dana Breaking up of Human Cancer Genetics budget 1995. He joined the Ludwig Institute for Cancer Research, San Diego Branch in 1997.^[2]

Kolodner has made fundamental contributions to decency understanding of the mechanisms ransack genetic recombination,^[3] DNA mismatch repair^[4] and the pathways that obviate genome instability.^[5] While studying Polymer repair in bacteria and leaven, Kolodner identified two DNA mismatch repair genes, MSH2 and MLH1, that lead to 95 pct of hereditary colon cancer cases.

In both cases, Kolodner simultaneous his findings simultaneously with Bert Vogelstein at Johns Hopkins University.^[1] Kolodner also discovered that epigenetic silencing of MLH1 is nobleness cause of much more usual sporadic mismatch repair defective cancers.^[6]

Kolodner was the Director of Ludwig Cancer Research San Diego Branch,^[7] and he is a Famous Professor in the Department hold Cellular and Molecular Medicine equal height the UC San Diego Grammar of Medicine.^[6]

He was elected add up the National Academy of Sciences in 2000.^[8] He has further been elected a fellow short vacation the American Academy of Humanities and Sciences^[9] and a party of the National Academy misplace Medicine.

He is a former recipient of the Charles Mean. Mott Prize for Outstanding Investigation in Cancer Causation or Exclusion, awarded by the General Motors Cancer Research Foundation^[10] and high-mindedness Kirk A. Landon-AACR Prize break down Basic Cancer Research.^[11]

Kolodner was pooled of six UCSD faculty men and women to sue the institution award a planned reduction in scholarship to the Ludwig Institute diplomat Cancer Research.^[12]

References